Ameliorative effect of zinc and vitamin-c against cadmium induced bioaccumulation in selected tissues of male albino rat
Kesavulu V, A Usha Rani
The present study was conducted to evaluate the toxic effects of cadmium on bioaccumulation and antioxidant enzyme status in Wistar strain male albino rats to determine the potential benefits of different antioxidant enzymes. Zinc (Zn) and Vitamin C (Vit C) are tested to know whether they have beneficial effects in ameliorating Cd induced toxic effects. To achieve this objective, albino rats (n = 6), weighing 180 ± 20 gm were treated with Cadmium Chloride (CdCl2) at a dose of 1/10th LD50/48 h i.e. that is 22.5 mg/kg body weight for 7, 15 and 30 days (d). Later 15d Cd treated rats were divided into three groups. The 1st groups of rats were subjected to Zinc (12mg/kg), 2nd group to Vitamin-C (200 mg/kg) and the 3rd group to combination of Zinc + Vitamin-C supplementation for 7, 15 and 30d time periods. After the specific time intervals, rat tissues were obtained and evaluated Bioaccumulation, Glutathione (GSH), Glutathione Reductase (GR) levels in liver, kidney and testis. Bioaccumulation in Cd-intoxicated rats were significantly increased with concomitant decrease in Zinc and Vitamin C concentration (P< 0.001) in Cd treated group when compared to the control group. More significant and beneficial effects were observed with Cd + Zinc, Cd + Vitamin C, and Cd + Zinc + Vitamin C treated groups in reducing Cd-induced bioaccumulation. Hence our present findings suggest that Zinc and Vitamin C have protective role in reversing the Cd induced bioaccumulation and exert beneficial effects in adult male albino rats by restoring antioxidant capacity.
Kesavulu V, A Usha Rani. Ameliorative effect of zinc and vitamin-c against cadmium induced bioaccumulation in selected tissues of male albino rat. International Journal of Ecology and Environmental Sciences, Volume 3, Issue 2, 2021, Pages 194-200