Environmental change is a pervasive and growing global threat to biodiversity and ecosystems. It has negatively affected most biological systems on our planet and is evolving into a distressing concern for the well-being and survival of many species. At an organism level, effects include decreased reproductive parameters and immuno-suppression that can directly lead to disease or increase the risk of acquiring disease. Living organisms strive to resist the environmental changes to maximum of their abilities. However, rigorous environmental changes may pose additional pressure on immuno-competence, which may seriously impact population viability and persistence. The importance of immune system for healthy survival is outlined and the effects of exposure to a rapidly changing environment are examined that primarily affect the immuno-competence. The potential deficits in reproductive parameters that might arise owing to new immune challenges in the context of a rapidly changing environment are highlighted. The future perspectives and research possibilities are also brought to light.