Trends in prescribing antidepressants for disorders other than depression is increasing all over the world. Environmental load of this contaminant may influence neuroendocrine systems of non-target organisms mainly in aquatic ecosystems. Antidepressants in low doses have significant genotoxic effects too. Most commonly studied impacts of this group of contaminants is disruption of normal behavior. Behavioral changes due to antidepressant contamination may result in drastic alteration in population size and community composition. From microbes to mammals all classes of living organisms are affected by antidepressant pollution. Ecosystems contaminated with antidepressants may lose their normal functions like nutrient cycling, energy flow, photosynthetic efficiency and respiration. All effects exerted by such neuroendocrine disrupters may have broader consequences in terms of evolutionary process.