Advances in plant molecular farming: More than a medicine for achieving sustainable biomanufacturing
Anju M Job, Biju S, Keerthiraj B
Plant molecular farming is a new and promising industry involving plant biotechnology and it is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. The development and improvement of the transient expression system has significantly reduced the protein production timeline and greatly improved the protein yield in plants. Plant based manufacturing can make the greatest impact, focusing on commercialized products or biopharmaceuticals including recombinant vaccine antigens, monoclonal antibodies, enzymes, and growth factors that are used as research-grade or diagnostic reagents, cosmetic ingredients, and biosensors or biocatalysts. Plants have emerged as a promising alternative expression system for production of pharmaceutical proteins because they offer several potential advantages, including low production costs, ease of scale-up to commercial quantities of production and reduced risk of product contamination by mammalian viruses or toxins. In this chapter, we discuss the technological basis of molecular farming in plants, with a focus on host systems and approaches/strategies developed to maximize protein yields and to ensure efficient recovery and purification of plant-made recombinant products.
Anju M Job, Biju S, Keerthiraj B. Advances in plant molecular farming: More than a medicine for achieving sustainable biomanufacturing. International Journal of Ecology and Environmental Sciences. 2020; 2(4): 328-333.